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KMID : 0869619950120040323
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Journal of Korean Society of Hospital Pharmacists
1995 Volume.12 No. 4 p.323 ~ p.327
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Weight Variation of Splitted Tablets
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하미애/Ha, M.A.
신숭휘/송보완/김종우/홍남두/Shin, S.H./Song, B.W./Kim, J.W./Hong, N.D.
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Abstract
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Although original tablets are almost fit in weight variation test, in many cases, tablets are practically splitted for dose control in dispensing. These splitted tablets are considered secondary cause of weight variation.
So, in this study tablets were classified into three groups by the average weight, first group was below 0.12g(A), second was more than 0.12g below 0.3g(B) and third was more than 0.3g(C). Each group consists of four kinds of tablet and weight variation after tablet splitting was calculated.
As a result, average violation rate of weight variation test was 60% for A group, 42.5% for B group, 55% for C group. And the relation of hardness of tablet was the higher rate of weight variation.
In conclusion, split of tablet for dose control in dispending was absolutely a cause of dose mistake. Especially drugs having side effect or toxic effect should be carefully when pharmacists split of tablet for dose control in dispending was absolutely a cause of dose mistake. Especially drugs having side effect or toxic effect should be carefully when pharmacists split tablets for dose control in dispensing.
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